The University of Arizona

 

 

Arizona Respiratory Center

 

Research

Maternal Influences on Asthma Development

During pregnancy, a woman's immune system undergoes changes that are particularly evident in her placenta. These changes also affect the immune function of her developing child. As a result, infants born to mothers with asthma have an increased risk of also developing asthma. This risk rises even higher if the mother smokes during her pregnancy.

Principal Investigator:

Mark A. Brown, MD

This study seeks to explain the role of a critical element of the immune system known as T-cells. These cells seem to play a key role in the body's responses to environmental factors leading not only to asthma but also to other allergic diseases, such as rhinitis and eczema. Changes in the immune function of babies born to mothers with asthma seem to involve this special type of immune cells.

Researchers hope that the results of this study will help them better understand the interaction between a mother and her developing baby. That improved understanding could then help researchers develop treatments to reduce the risk of asthma and other allergic diseases in the children of women who have those diseases themselves.

Primary focus: Asthma


The University of Arizona College of Medicine

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