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Professional Education
This Course took place on February 27,2002 at the Sheraton Tucson Hotel & Suites
For further information, please contact Donata Vercilli, MD
An Introduction to the Genetics and Genomics of Complex Lung Disease
Course Directors: Donata Vercelli, M.D., and Lyle Palmer, Ph.D.
Designed for physicians, scientists, and students, this educational course offered by the NHLBI Program for Genomic Applications (PGA) seeks to provide an introduction to and an overview of, the role of genetics in the pathogenesis of complex lung disease (asthma, COPD), and the methods to discover and analyze genetic polymorphisms. Speakers are leaders in the field from the Arizona Respiratory Center, University of Arizona, the Channing Laboratory, Harvard Medical School, and the University of Washington.
No registration fee is required for this course.
Target Audience
- Physicians, Scientists, and Students interested in using modern genetics to understand complex diseases
Course Objectives
- Discuss the main genetic pathways involved in complex lung disease (asthma, COPD)
- Explain the role of genetic variation in the pathogenesis of complex lung disease
- Discuss the importance of innate immunity in the pathogenesis of complex lung disease
- Introduce to methods to discover and analyze genetic variation in complex lung disease
- Discuss functional genomics studies that have highlighted mechanims of disease in the lung
Course Agenda
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Introduction |
8:00 a.m.
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The UA/BWH Genome Center
Fernando Martinez, M.D., Arizona Respiratory Center, University of Arizona, Tucson, AZ |
8:20 a.m.
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The Role of Innate Immunity in Human Disease: An Introduction
Donata Vercelli, M.D., Arizona Respiratory Center, University of Arizona, Tucson, AZ |
Genomics |
9:00 a.m.
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SNPs in the Human Genome and Linkage Disequilibrium
Deborah A. Nickerson, Ph.D., University of Washington, Seattle, WA |
9:40 a.m.
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The Role of Bioinformatics in SNP Discovery and Analysis
Alberto Riva, Ph.D., Channing Laboratory, Brigham and Women's Hospital/Harvard Medical School, Boston, MA |
10:20 a.m.
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Break |
10:40 a.m.
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Discovery of Sequence Variants in Innate Immunity Genes
Walt Klimecki, D.V.M., Ph.D., Arizona Respiratory Center, University of Arizona, Tucson, AZ |
11:20 a.m.
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Genotyping Technologies, and Application to Innate Immunity Genes
David Kwiatkowski, M.D., Ph.D., Brigham and Women's Hospital/Harvard Medical School, Boston, MA |
12:00 p.m.
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Lunch |
Methods |
1:00 p.m.
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Gene-Mapping Studies in Complex Disease: Methodological Concerns and Study Design Issues
Lyle Palmer, Ph.D., Channing Laboratory, Brigham and Women's Hospital/Harvard Medical School, Boston, MA |
1:40 p.m.
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An Introduction to Gene Localization in Asthma and COPD
Ed Silverman, M.D., Channing Laboratory, Brigham and Women's Hospital/Harvard Medical School, Boston, MA |
2:20 p.m.
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Break |
Genetics & Molecular Mechanisms
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2:40 p.m.
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The Genetics of IL-13
Scott Weiss, M.D., Channing Laboratory, Brigham and Women's Hospital/Harvard Medical School, Boston, MA |
3:20 p.m.
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Innate Immunity in Allergy and Asthma: The Story of IL-10 and CD14
Fernando Martinez, M.D., Arizona Respiratory Center, University of Arizona, Tucson, AZ |
4:00 p.m.
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Functional Genomics of CD14 and the Allergic Response
Donata Vercelli, M.D., Arizona Respiratory Center, University of Arizona, Tucson, AZ |
4:40 p.m.
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Conclusion |
5:00 p.m.
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Reception/Mixer |
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