The University of Arizona

Sairam Parthasarathy, MD

Director, Center for Sleep Disorders
Program Director, Sleep Medicine Fellowship Program
Professor of Medicine


Sairam “Sai” Parthasarathy, MD, is a NIH- and PCORI-funded researcher who serves as an Associate Professor of Medicine, Director of Center for Sleep Disorders, and Associate Director for Arizona Respiratory Center at the University of Arizona. Sai’s research focuses on the relationship between sleep, breathing, and inflammation in both ambulatory and critically ill patients. Additionally, he has been involved in clinical trials of novel modes of ventilatory assistance for patients with sleep-disordered breathing (such as servo-ventilation and volume-assured pressure support) as well as health services research aimed at improving healthcare delivery and promoting CPAP adherence in patients with sleep-disordered breathing. He serves as the program director for sleep medicine at the University of Arizona and is involved in training clinical and research fellows in sleep medicine. He previously served as Chairman of the Sleep Disorders Research Advisory Board (SDRAB) to the National Center for Sleep Disorders Research (NIH/NHLBI) and currently is an Associate Editor for the journals SLEEP and Journal of Clinical Sleep Medicine, and is on the Editorial board of the American Journal of Respiratory and Critical Care Medicine. He previously served as the Chair of the Research Committee of the American Academy of Sleep Medicine, Chair of Young Investigator Forum conducted at the NIH, as an ad-hoc reviewer for NIH and PCORI review sections. He is board certified in Sleep Medicine as well as Pulmonary and Critical Care Medicine and has published over 80 papers and book chapters on sleep- and respiration-related topics.  Research studies include: Sleep intervention during Acute Lung Injury (R01 NIH/NHLBI; HL095748):The central purpose of this proposal is to study the short-term effects of sedation with sympatholysis on sleep and inflammation in critically ill patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). #NCT01050699 Peer-Driven Intervention as an Alternate Model of Care Delivery and Coordination for Sleep Apnea (Funded by PCORI; IHS-1306-2505):The overarching goal of this study is to improve patient-centered outcomes using peer-driven intervention and an itneractive voice response system in patients with sleep apnea. #NCT02056002 Chronic moderate sleep restriction in older long and older average sleepers: The proposed clinical trial will provide the most comprehensive Phase 1 assessment of risks and benefits of chronic moderate TIB restriction ever conducted. (R01-HL095799 (MPI): Youngstedt, Parthasarathy, Irwin, Jean-Louis) Comparative-effectiveness of CBT-I and CAM in facilitating sleep in ICU survivors (Johrei Foundation): The primary purpose of this grant proposal is to compare CBT-I and CAM as therapies for sleep disturbances in survivors of critical illness. Obesity and obstructive sleep apnea in hepatocellular carcinoma progression (PQA2) 1R21CA184920: Test the effect of chronic intermittent hypoxia (IH) on the progression of fatty liver and chemically-induced hepatocellular carcinoma (HCC) in lean and diet-induced obese (DIO) mice. Also, to determine the role of HIF-1α on hepatic lipid accumulation and HCC progression in response to DIO and chronic IH.


Sleep intervention during Acute Lung Injury (R01 NIH/NHLBiHL095748): The central purpose of this proposal is to study the short-term effects of sedation with sympatholysis on sleep and inflammation in critically ill patients with acute lung injury(ALI) and acute respiratory distress syndrome (ARDS). NCT01050699

Positive airway pressure therapy for sleep-disordered breathing (ADVENT-HF; Canadian Institute of Health Research [CIHR] and Toronto Rehabilitation Institute, Toronto, Canada): The central purpose of this proposal is to assess the effect of adaptive servo ventilation (ASV) on mortality and cardiovascular hospitalizations in ptients with chronic heart failure and sleep apnea.

Adherence to CPAP Therapy in patients with sleep-disordered breathing (US Dept. of Veterans Affairs; PPO 10-066): Our overall aim is to assess the feasibility and acceptability of a CPAP adherence program driven by trained "peer-buddies" with sleep apnea. NCT01164683

Sleep deprivation in murine models (Johrei foundation): The central purpose of this proposal is to study the sleep-promoting effects of Johrei treatment in a murine sleep deprivation model.

More information about Dr. Parthasarathy's Lab

Research Specialties: 
Sleep Medicine