The University of Arizona

BARD

Summary: 

The purpose of the study is to find the best asthma treatment for African American asthmatics who are not well controlled on low dose of inhaled steroid.


Researchers: 

Research Specialties: 
Asthma

BTR Study

Summary: 

A prospective observational study of biopredictors of Bronchial Thermoplasty Response in patients with severe refractory asthma.


Researchers: 

Research Specialties: 
Asthma

PROSPERO

Summary: 

A Prospective Observational Study to Evaluate Predictors of Clinical Effectiveness in Response to Omalizumab


Researchers: 

Research Specialties: 
Asthma

TCAP - Randomized Trial of Ticagrelor for Severe Community Acquired Pneumonia

Summary: 

To assess the efficacy and safety of 90 days of oral ticagrelor in patients hospitalized with severe community acquiresd pneumonia (CAP).  The primary objective is to reduce all-cause mortality in the ticagrelor group compared to the placebo group.

Sponsor: 
Gordon Bernard AstraZeneca


GRADS Alpha-1 Antitrypsin Deficiency

Summary: 

Alpha-1 Antitrypsin Deficiency is a genetic condition that predisposes to early onset pulmonary emphysema and airways obstruction, often indistinguishable from usual smoker's chronic obstructive pulmonary disease. The purpose of this study is to study the air way and lung microorganisms in people with Alpha-1 Antitrypsin Deficiency or individuals in the carrier status and the inflammatory response.

Sponsor: 
he National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI)


Research Specialties: 
Pulmonary

GRADS-Sarcoidosis

Summary: 

Sarcoidosis is a systemic disease characterized by the formation of granulomatous lesions, especially in the lungs, liver, skin, and lymph nodes; it has a heterogeneous set of clinical manifestations and a variable course for which there is not efficient long term therapies. The purpose of this study is to analyze the distinct patterns in lung microbiome (microorganisms) characteristic of Sarcoidosis and changes in the genes that impact the inflammatory response.

Sponsor: 
National Heart, Lung and Blood Institute (NHLBI) of the National Institutes of Health


Research Specialties: 
Pulmonary

Simtuzumab (GS-6624)

Summary: 

This study is to evaluate the efficacy and safety of simtuzumab (GS-6624) in adults with idiopathic pulmonary fibrosis.

Sponsor: 
Gilead Sciences

Researchers: 

Research Specialties: 
Pulmonary

RISE

Summary: 

Comparing the Efficacy of Symbicort® pMDI and Formoterol Turbuhaler in Reducing Exacerbations in Patients With Cronic Obstructive Pulmonary Disease (COPD)

Sponsor: 
AstraZeneca


Research Specialties: 
Pulmonary

A Comparison Study Between the Fixed Dose Triple Combination of Fluticasone Furoate/ Umeclidinium/ Vilanterol Trifenatate (FF/UMEC/VI) With Budesonide/Formoterol in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

Summary: 

This is a phase IIIa, randomised, double-blind, double-dummy, parallel group multicenter study evaluating once daily FF/UMEC/VI (100 microgram [mcg]/62.5 mcg/25 mcg) inhalation powder versus twice daily budesonide/formoterol (400 mcg/12 mcg). The primary purpose of this study is to demonstrate improvements in lung function and health status for subjects treated with FF/UMEC/VI compared with budesonide/formoterol for 24 weeks. Once-daily 'closed' triple therapy of a Inhaled Corticosteroid/ Long-acting Muscarinic Receptor Antagonists/ Long Acting Beta-Agonist (ICS/LAMA/LABA) combination FF/UMEC/VI (100 mcg/62.5 mcg/25 mcg) in a single device is being developed with the aim of providing a new treatment option for the management of advanced (GOLD Group D) COPD which will reduce the exacerbation frequency, allow for a reduced burden of polypharmacy, convenience, and increase the potential for improvement in lung function, Health Related Quality of Life (HRQoL) and symptom control over established dual/monotherapies. 

Sponsor: 
GlaxoSmithKline


Research Specialties: 
Pulmonary

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