The University of Arizona

Kenneth S. Knox, MD

Division Chief, Pulmonary, Allergy, Critical Care, & Sleep Medicine, Department of Medicine
Professor of Medicine and Immunobiology
Vice Chair for Education, Department of Medicine
Murray and Clara Walker Memorial Endowed Research Chair


Dr. Knox is known nationally for his research and clinical expertise in sarcoidosis, fungal diagnostics, and immunologic lung disease. His nationally funded research utilizes bronchoalveolar lavage (BAL, a “lung wash” done through an endoscope) to study the mucosal lymphocyte response to a variety of infectious and inflammatory diseases including the human immunodeficiency virus (HIV), cytomegalovirus (CMV), endemic fungal pathogens and rheumatologic lung disease.

Dr. Knox joined the UA College of Medicine in 2008. He served as chief of medicine for the Southern Arizona VA Health Care System in Tucson, where he was instrumental in the transition to a closed staffing model in the intensive care unit. He is board-certified in pulmonary, sleep and critical care medicine.

A native of Youngstown, Ohio, Dr. Knox graduated cum laude with B.A. in Microbiology from Miami University in Oxford, Ohio. He obtained his medical degree and residency training in Internal Medicine at Ohio State University. He completed a fellowship in Pulmonary/Critical Care/Sleep Medicine at Indiana University in Indianapolis, where he also served as educational director and director of the immunologic lung disease program.

American Thoracic Society (ATS)
American College of Chest Physicians (ACCP)
The ATS Project Committee: Statement on complications of biologics
American Thoracic Society MTPI Assembly Programming Committee


Dr. Knox and his research lab focuses on using bronchoalveolar lavage (BAL) for immunodiagnostics and lung immunity. He employs BAL in human subject cohorts to study mucosal immunity in a clinically relevant context. He has been funded to perform longitudinal translational studies, correlating immunological findings and the lung microbiome with clinical disease in HIV.

Dr. Knox and his research team aim to understand the causes of HIV-associated chronic obstructive pulmonary disease (COPD), pulmonary hypertension, and immune reconstitution inflammatory syndrome (IRIS). People infected with human immunodeficiency virus (HIV) – the virus that causes AIDS – commonly develop lung disease. Dr. Knox and his team are studying the role of pulmonary inflammation in the development of HIV-related lung diseases funded by a collaborative U01 grant from the National Heart, Lung, and Blood Institute.

Dr. Knox is building a patient registry in regards to people with respiratory-related diseases, to better understand lung disease and to improve care of those afflicted. This patient registry will include people with respiratory-related diseases cared for by the providers at the University of Arizona. The registry will be used to describe the types of people treated for lung disease at the University of Arizona clinics and to identify those who may be eligible to participate in future studies.

Research Specialties: 
Critical Care
Sleep Medicine